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Indeed, impaired intestinal barrier, endothelial dysfunction, and pro-inflammatory response induced by LPS translocation have been shown to seriously affect the development of CVD

For example, targeting mTORC1 with rapamycin and AKT with MK2206 has been shown to increase radiation sensitivity in breast and non-small cell lung cancer models

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Lokker N A, Mark M R, Luis E A, Bennett G L, Robbins K A, Baker J B and Godowski P J (1992) Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding

Evans EPP, Scholten JTM, Mzyk A, Reyes-San-Martin C, Llumbet AE, Hamoh T et al (2021) Male subfertility and oxidative stress